Sperm/egg Curation

Avoidance of dysgenic pressures and a healthy genepool stock to start with. Mostly self regulating, except perhaps for monitoring for any founder effect genetic defects .... recessive ones might amplify without showing up until they achieve a certain saturation point. These are usually either completely neutral if only present as one allele or remnants of some old adaptive tradeoff against epidemics which are no more an important factor. The follies of civilization have bent humanity out of its natural shape, priorities should be right with this issue.

If you're just selecting things that are in the healthy and understood ranges of present examples there would be only very rare issues that could be corrected in the next "round" (generation)

We can try to catch these issues by studying smaller lab mammals.

Yes, but, evolution selects for reproductive success, and it selects based on the environment. What you would be trying to do with genetic modification is to basically micromanage this process. I have a hard time believing that we would be able to do this successfully, unless we knew everything about everything, only then would I be comfortable with that.

I guess the question is this: Is there any way in which we can actually do better than evolution? I have no idea obviously, but I think that we should actually know first, before doing any genetic modification on humans.

This is also like they say more variation within a group than between groups. Biases aside the biggest issue is intellect and lactose intolerance. Some people would need selective breeding options just to have the traits in the pool at all. But usually it's either these types don't reproduce at all in an urbane environment or they do breed up quickly. Flynn effects etc.

You're taking the idea out of it's real useful scope. You'd only do this on a needs basis and like once every day 5 to 10 generations. Even then also you're only looking at incremental advantages as the goal.

Okay, maybe I am misunderstanding something. Can you tell me what issues you'd actually want to solve with genetic modification? If we use it sparingly, why use it at all and risk the negative consequences.

People would probably make laws to limit the frequency and scope of selections allowed at all anyway. Then I would suggest a case by case system and a lottery and a pay to win system.

First off it is categorically not a modification at all. That's the wrong term. It's purely selective. It's like curating a gallery of paintings. Please use the correct term so you don't freak people out.

You use it a lot at first really to fix obvious stuff like vitamin deficiencies and really simple defects as in anything you can identify binarily. That way the effects are really well understood issues. If you have a sample of say 1k sperm you could statistically only fix issues that require 9 genes to be optimized through selection(curation) and even then you'd just use algorithms to tell you a set of options which might be super lucky or essentially neutral.

Some things are just as simple as like a single lever pulled but they change a whole health condition that could cost thousands of dollars a year to treat as best as is even possible.

In some cases, what is more towards the basic stuff. Household genes, basic immune function, that stuff ... when it comes to the "finer print" a mouse is often too different already. Chimeric gene insertion in many cases is simply too "Frankenstein" to provide reliable data either. If studying things like long term effects of metabolic genes for example an animal model is still useful, unless it could e.g. be replaced with a human tissue organoid for example. In other cases in vitro studies are simply superior. In immunology for example you can easily obtain human stem cells from blood with no harm done ... btw a good point here perhaps, a human is not simply genetics. More like the product of genetics in a lifetime interaction with environ. There are pitfalls here if for example screening big data for a correlation between a pathology and gene variants ... the gene variants might actually be benign or even beneficial unless confronted with an environmental factor that should not even be there to begin with ...

Maybe with huge improvements to the efficiency and the momentum gained over time of gradual improvements by the 41st millennia we'll all be space marine material physically anyway. But I don't think people would go for that at all even if they could.

Niche cases yes for the midwits audience is mostly this list of concerns. An informed council would suggest limitations to the scope and pace and frequency of the practice because of these things yes. The idea it's a legitimate reason to never do it at all isn't supported by anything very logical.

but have a moral code against genetic modification.

It's your language, but fine.

My point is that even if you can do all of that perfectly, without error, so not risking any erroneous humans resulting from it, it would still be very difficult to understand the downstream effects of very simple changes. So I would say, unless you can understand all of these downstream consequences, don't do it, but I imagine it would require much more than understanding genetic science.

So all I am doing is arguing that we would need to know a lot more than genetic science. Then, sure, let's do it.

Is there any way in which we can actually do better than evolution?

In specific cases perhaps, where it got its blind spots. A shoddily suppressed and passed down endogenous retrovirus without any repurposed biological function for its "host" and only the potential for catastrophic suppression failure would sure not be unwise to be deleted. Or perhaps damaged beyond functionality by clever point mutations (might just still have some obscure spacer function for the chromatin after all). It might be worth the effort in some cases, for example if thinking about offworld missions ... one big liability if radiation creates a break at such sites, reawakening the dormant parasite early (the little shits exploit DNA repair to un-repress themselves). Pic related for dramatic effect. ;)

Most of the comments unconnected to other concerns here are on the scope and premise of the idea because genetics is a hugely complicated and central subject so I'm focusing on all the fires it lights to even bring up any idea about it at all.

That's definitely more like changing a cars grill than the engine design first.

There is definitely no good reason to never consider it at all. If we exclude outright idiocies or complete blind hubris there would be little overall damage potential if certain careful modifications (like fixing obvious evolutionary junk as in my prior comment) would be introduced into the overall genepool. They´d come under selective dynamics and either integrate and attain prevalence or simply get outcompeted again. Yes, a generational way of thinking but anything else would likely prove too rash and unpredictable.

Why the fuck did I even get involved, I know nothing about this lol.

complete blind hubris

your language, but fine.

I didn't invent English. It's not supposed to be subjective in meaning, just to have words that also span subjective interpretations. You could say accurately that genetic curation is intervention but to make it illegal would be the same in principle as getting rid of IVF and donations and that thing they do for same sex couples. Well actually that is a modification.

You're doing fine. But to be blunt. The power of a God.

So to be exact and reduce confusion you would need to modify the zygote cells to access the information of the DNA with present technology, so it's a cellular intervention if not technically modification if you use a different cell to carry the DNA. People modify their cells all the time though. Pick your nose and you killed a few of them. Drink alcohol or pinch yourself or put on sunscreen whatever.

You've sold me, let's do it. Let's eliminate the undesirable trait of niggerness.

Uh but if people are going to work in space consistently in the future like planetes it would be prudent to do this for every generation and just attempt to stay competitive as possible. Of course sometimes people not accelerated by this would just goat anyway.

come on man.
NIGGERS can´t even reproduce the technology that biult the pyramids, and we are slave to usury, and NOW with genetic editing things will get better? get real, it´s just another way for jews poisoning us, they are already make people sick and dumb with their current poisons, now they wanna corrupt entire DNA lineages, so that they can ensure their power over the minds of the weak,feeble, sick and dumb people that will be born for generations if you start advancing genetics.
in the end, jews stole alexandria libraries but could not get to understand any shit of it beyond usury, so they will use white slave goyims that will decipher it for jews, so that the information that was used in the past for progress of humanity, will be used for jews to sabotage humanity again and forever.
until there is not even a single white people alive, and they overcome this entire planet with their cursed lineage, that already destroyed the entire mars with their kikerism, and now they moved here to destroy earth as well.
the best course of action in a rigged game IS NOT TO PLAY.

Astronaut traits also aren't more competitive really except in a nuclear wasteland or something. It's not very controversial.

Jews interbreed consistently with everyone else so most of the relevance to any concept of them as a distinct people is fading. It's a different set of cultural ideals but usually ones that other people are prudent to adopt anyway. The poisons I mean Republican or fasci white and Asian people are far worse at not being environmentalists because they keep accelerating industrial consumption before cleaner wiser options have reached economic mass. As far as concepts of genetic corruption that's mostly the consequences of hypergamy. Women looking for perfection don't settle for maintenance like a person trying to sprint gasses out in a marathon. Jews are always in the news like gun crime when it's basically as rare as lightning or earthquakes. Trust me there are lots of other people in other groups that have more real power.

Women are retarded, but the problem is that most men are as dumb as you so not exactly a better option for boss.

Memes.

Download my code for percent percent off

But anyway, if you let people do actual like designer babies they'll just make the whole world be full of hypersexual teenagers that sell feet pics for a living.

Jews interbreed consistently with everyone else so most of the relevance to any concept of them as a distinct people is fading.

they are indeed distinct but is not fading their breeding strategies, use their cursed dominant(not recessive) genome to mix with the rest of entire human race, as a parasitical Gene/DNA that will trigger unhuman behavior, physiognomy and wickness.

Trust me there are lots of other people in other groups that have more real power.

what is power when the entire world has your cursed genes? not absolutely the entire population now have it, but their plan is exact that! this is why the great flood was done by God the creator to flush the entire world of jews, this is why only Noah family was the only one pure white left, in the end the curse of Cain, a hybrid mix of Adamic lineage and a cursed querubin still roams the earth and wanted to destroy the adamic lineage completely.
the people who you think have more power, are just the same people disguised as another tribe or faction, but in the end they are always the same genetically.
it´s like thinking arabs and jews are different when in reality they are cousins.

I bought metro and an uncharted set and I'm thinking with this idea like doing a fairly hard sci fi planetes type movie where I would cast spider dude, but idk if I would want it to be like a future where a limited nuclear exchange caused portions of I would say Russia to be irradiated and there's stuff that's metro esque. Just to tie together the space and nuclear fallout concepts. It's a setting you could do interesting things in. And instead of marvel or uh not Johnny what's his name? He man iron man idk sorry you have a cameo of Tom Cruise doing high intensity stuff like fighting himself in oblivion. Idk. And it's also a romance sort of because in the future astronauts are always in a relationship together.

I'm not going to respond to your illiterate ideas. Go study more.

You're right, but at that point, why not just do dna modification?

You don't understand just how limited this idea is compared to that. It's like the difference between driving a car and lighting a coal vein on fire to cause climate change.

And people aren't corn. It actually would be horrendous to think about our genetics that way.

Jep, or simply removing a fatal design flaw. Nature would get rid of the example I have given with enough time but it is under very little pressure to do so ... just genomic drift slowly grinding the bad sequence down.

Haha, do not need to be an expert to participate in the more philosophical side of this topic. To rephrase, nature did another "eh, good enough" job with these genomic parasites we carry ... tidying up after that would sure be one example where genetic meddling could be a worthwhile thing to do ... ^^

So tom crashes in Russia but it's an irradiated zone and he needs to get out really fast so it's like day z sort of. Maybe there are drones to avoid too looking for him. And then Tom Cruise is just some Russian character who has a completely separate story that just happens to collide with him and they fight just out of suspicion but he's obviously not decided to hurt tom or anything just he's weirded out. Then idk like he says I'm actually an astronaut and tom goes f it I'll believe you and flies him to the other crash site where his gf partner landed. The post war leads to skepticism of everyone so the danger isn't that Russia hates them but that Russians don't know or believe him.

Anyone think we could make money using SpaceX to put a green screen studio in LEO?

I know you're all thinking space sex scenes.

I suppose you have a point. Just seems kind of convoluted is all.
I was actually not thinking about that.
But now I am, thank you for putting that image in my head.
Newtonian movement in freefall while banging. If you cum hard enough she could rocket off of your penis like one of those toy water bottle rockets.

Hm. I'd imagine that military satellites have to be equipped to dodge each other because their orbits are not shared with other countries and they don't like want to collide and make Kerbal impossible. For no reason anyway. The plot can be a collision because uh it's a decommissioned satellite and your thrusters malfunctioned.

Oh but like all the countries are much bigger despite the local anarchy. Eurasia is one, Asia majoris, and the two Americas. Population is estimated to 700 to 1000 million.

Yeah transhumanism with le machine is retarded, the flesh is also a machine and has endless potential, we just lack the fucking sciences involve. That's about it.

To the genetic tie in as an example I'm full blown bipolar but I inherited that from like two sort of bipolars and that leads to emotional stresses from like for instance I only have the motivation to do the bare minimum of self care. And a marriage is tough if you're already naturally emotional. So like the idea is like in a post nuclear zone even if the world has the idea of cooperation together now doesn't mean it's easy with all the no go zones and green stuff around. So it's like artistic and shit.

Perhaps for the species targeting libido and emotional or cognitive abrogations would be the thing that really improves species survivability and surface livability.

Yep that's the tldr

Hm but if you have to fly ... Maybe Tom is definitely some like I would say a survivor of a splinter remnant of intelligence operatives of unspecified loyalties and he knows where an "old" jet that's basically perfect by our imaginations is and it's actually just the knock off for that time and they have to repair it some or at least do checks but why were designed to last because of scenarios like these being so likely. Then why is it so important to move him? It's not. That's just what tom was doing anyway.

And Tom isn't super knowledgeable so he doesn't even think he can get it running but he's going anyway to scope the job out and because he needs that skill set he's like well gee an astronaut. Damn. What luck.

And one thing tom does in the rad zone is recover abandoned mil equipment like an experimental mobility assistance system. Kind of like a harness of mech legs and a pretty hefty battery pack in the lower back area.

It's like a multi day journey but he uses cellars that didn't really get contaminated to hide from search parties and stay out of the rads while planning etc.

testt

He has this AI assistant device you ask questions like please translate this map or signs I've seen and provide educated suggestions of spots to scavenge quickly.

And the mech legs do have wheels for flat and gravely or dirt and grass surfaces

But he also uses cars where possible or even gliders.

I'm kind of thinking like what a really desperate person would do to try and run faster. Like they extend their calves fully and extend their stride by making each step into a sort of cushioned stomp. Like how a power stroke works. And you see it on their face they're gritting like they're trying to punch through bullet proof glass before they run out of air. Because a drone is trying to strafe them. Like they say athletes learn to do like 35 % muscle strength activation but I bet it's higher for karate. Just complete muscular destruction though.

I had the same idea and I think it will be done as soon as technically possible but we won’t get to know, as it would be available only to the elites.
It might already be happening now…

But really you just act the emotions and form but we speed the tape up 15 percent

But it's complicated because you have to span the gap in like say 9 seconds but also you have to preserve your top speed to accelerate unexpectedly. So you're not really saving your strength at first as much as priming your mind to exert for the second phase and it's a lot like the resolve to do ballistic wound first aid on yourself.

Well the problem with that is that a limited option is prudent for key issues for others. Like selecting out things that lead to behavioral issues for instance. You could just sequence a few and not care about other details.

The strength of the idea is that the more we understand about genetics you're able to pick between multiple whole persons so you don't really need to design them or whatever. Or be elitist. There's just deal breakers is all.

It's actually weird but if a person is highly intelligent and not a psychopath there's some benefit to having an individual that does have a little bipolar and schizophrenia because it's like using algorithmic compensation for an inherently unstable bicycle. And they probably won't kill anyone.

Sorry for not taking a picture but that was funny.

We should never start with any crispr bullshit, the first 100 years maybe humans will be stronger better etc.. BUT as we hand more say in our reproduction in the hands of computers..down the line we will evolutionary lose our biological reproduction and computers will have humans as worker ants, our life goal will be the reproduction of the machines, like how RNA first was the boss and used DNA as a helper but in the end the tables were flipped

have anyone read JFG book the phenotypical revolution

Idk what you mean but I kind of think having skin the color of the comment fields seems kind of based to me. Little too red maybe add more green and 2 blue.

Existing common colors have too much baggage imo.

It would look durable but polite. Inviting but reliable.

And pretty cool with any color of hair that isn't too light.

And kind of like a hog yes. But if you call a hog a bitch it'll just eat you.

Think about it. Even baki couldn't do shit to a hippo.

Aw shit, call maintenance, one broke down again.

Elephants don't have enough blubber. That other stuff makes sense to me. Yep.

Hippos got fat on their eyes even. No weak spots.

Anyway halfway between Klingon and boo is what I mean.

Desert mesa pastels.

So I guess actually it makes more sense if tom knows tom is an astronaut and is actually trying to help him help himself from the start.